![]() ![]() Patients could receive all necessary therapies for stroke treatment according to clinical practice guidelines and standard of care, and are being followed up for 18 months. Treatment continued until Day 30, then tapered off. Patients at high risk of developing unprovoked seizures after acute intracerebral haemorrhage or acute ischaemic stroke were randomised to receive ESL 800 mg/day or placebo, initiated within 120 hours after primary stroke occurrence. We outline the design and status of this antiepileptogenesis study, and discuss the challenges encountered in its execution to date. Experimental animal models suggested a potential antiepileptogenic effect for eslicarbazepine acetate (ESL), and a Phase II, multicentre, randomised, double-blind, placebo-controlled study was designed to test this hypothesis and assess whether ESL treatment for 1 month can prevent unprovoked seizures following stroke. There is currently no evidence to support the use of antiseizure medications to prevent unprovoked seizures following stroke. Epilepsia Open - 2023 - Koepp - Antiepileptogenesis after stroke trials and tribulations Methodological challenges and.pdf
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